What PSMA PET/CT offers
It combines molecular and anatomical information:
- locating primary, lymph node, and bone lesions
- assessing biochemical recurrence
- better mapping the extent of disease
It is an important tool in a personalized oncological strategy.
Main indications
It is often used in:
- initial staging of intermediate or high-risk disease
- biochemical recurrence after definitive treatment
- choosing the appropriate systemic or focal therapy
No detectable PSMA-avid disease
No suspicious foci are identified at the current sensitivity of the test.
Limited disease
A localized extent that often allows targeted treatment options.
Extensive disease
Multiple foci requiring a systemic oncological strategy.
Limitations and correct interpretation
Despite its high accuracy:
- false positives or false negatives can occur
- experienced joint nuclear medicine and urology assessment is required
- the treatment decision remains multifactorial
How it directly affects treatment
The result can change:
- the disease stage
- the radiotherapy field
- the choice of systemic therapy
- the indication for metastasectomy or a targeted approach
